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Epigenetic Reprogramming via Yamanaka Factors Demonstrates Tissue Rejuvenation in Initial Trials
Source: Nature Biotechnology · DOI: 10.1038/s41587-026-01
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Scientists have successfully initiated human trials of an experimental gene therapy designed to reverse cellular aging. By using specialized genetic reprogramming signals (OSK factors), researchers are prompting old, degraded cells to behave like healthy, younger cells again — potentially reversing age-related blindness and systemic organ decline.